Manuscript accepted at JCI!

Our manuscript “The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation” has been accepted by The Journal of Clinical Investigation! This work identified SIRT2 as a conserved regulator of adaptive beta cell proliferation that acts through a unique mechanism: regulation of glycolytic and TCA enzymes. Huge shoutout to PRA Sean Lee for developing high-resolution confocal microscopy in the new lab to help us get this across the finish line, with assists from our new collaborators Victor Ruthig and Kristen Wells-Wrasman.