Matt Wortham Matt Wortham

Manuscript accepted at JCI!

Our manuscript The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation has been accepted by The Journal of Clinical Investigation! This work identified SIRT2 as a conserved regulator of adaptive beta cell proliferation that acts through a unique mechanism: regulation of glycolytic and TCA enzymes. Huge shoutout to PRA Sean Lee for developing high-resolution confocal microscopy in the new lab to help us get this across the finish line, with assists from our new collaborators Victor Ruthig and Kristen Wells-Wrasman.

Read More
Matt Wortham Matt Wortham

Diabetes Day!

Don’t miss the CU DRC Diabetes Day at Shore Family Forum on March 21st! Matt will give a talk about de novo lipogenesis in the beta cell.

Read More
Matt Wortham Matt Wortham

HIRN Meeting

It all begins with an idea.

The lab is attending the HIRN Annual Meeting in DC on Jan 13-14th. Matt will be participating in Tuesday’s Breakout Session “Transition: Graduate student & postdoc to the next stage - including positions in Pharma, Industry and non-profits”. To commemorate 10 years of HIRN, this meeting is open to the public for the first time - be sure to register if interested.

Read More