The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation

Wortham M*,#, Ramms B*, Zeng C*, Benthuysen JR*, Sai S, Pollow DP, Liu F, Schlichting M, Harrington AR, Liu B, Prakash TP, Pirie EC, Zhu H, Baghdasarian S, Lee ST, Ruthig VA, Wells KL, Auwerx J, Shirihai OS, Sander M#. J Clin Invest. In press. *equal contribution, #corresponding authors.

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

Wortham M, Liu F, Harrington AR, Fleischman JY, Wallace M, Mulas F, Mallick M, Vinckier NK, Cross BR, Chiou J, Patel NA, Sui Y, McGrail C, Jun Y, Wang G, Jhala US, Schüle R, Shirihai OS, Huising MO, Gaulton KJ, Metallo CM, Sander M. J Clin Invest. 2023 Apr;133(8):e165208.

Systemic LSD1 inhibition prevents aberrant remodeling of metabolism in obesity

Ramms B, Pollow DP, Zhu H, Nora C, Harrington AR, Omar I, Gordts PLSM, Wortham M#, Sander M#. Diabetes. 2022 Dec;71(12):2513-2529. #corresponding authors.

Transcriptional mechanisms of pancreatic beta cell maturation and functional adaptation

Wortham M, and Sander M. Trends Endocrinol Metab. 2021 Jul;32(7):474-87.

Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic beta cell function

Wortham M*, Benthuysen JR*, Wallace M, Savas JN, Mulas F, Divakaruni A, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy A, Yates JR, Metallo CM, Sander M. Cell Rep. 2018 Dec;25(10):2904-2918.e8. *equal contribution.